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• Discuss specific use of drug and side effects with patient as it relates to treatment. After 2 years of treatment, increased mortality was seen in a long-term (median treatment exposure: 4.6 years) study at higher doses (20 to 80 mg depending upon weight 3 times/day) (Barst 2012a; Barst 2012b). • Hepatic impairment: Use Fildena with caution in patients with hepatic impairment; use lowest starting dose (25 mg).Â
Educate patient to seek medical assistance for erection lasting >4 hours. Filagra for erectile dysfunction should be limited to 25 mg every other day with close monitoring for Filagra toxicity. Management: Avoid Filagra when used for treatment of pulmonary arterial hypertension in patients receiving boceprevir.Â
Protease inhibitors: Maximum Filagra dose: 25 mg every 48 hours. It is unclear if these benefits would remain with long-term therapy or if potential drug interactions may limit usefulness in antidepressant-induced sexual dysfunction. Most of the published information suggests that Filagra may be effective in antidepressant/antipsychotic-induced sexual dysfunction, although a mechanism of action for this use has not been established.Â
A systematic review of the available data (two retrospective case series, one prospective open-label study, and one case report) found that Filagra significantly improved mPAP in patients with recent LVAD placement and persistent pulmonary hypertension. Hepatic via CYP3A4 (major) and CYP2C9 (minor route); major metabolite (UK-103320 or desmethylFilagra) is formed via N-desmethylation pathway and has 50% of the activity as Filagra. Fildena: 25 mg, 50 mg, 100 mg contains fd&c blue #2 aluminum lake.https://efildena.com/es/